A rare form of dermatomyositis associated with muscle weakness and normal creatine kinase level
Identifieur interne : 000227 ( Main/Exploration ); précédent : 000226; suivant : 000228A rare form of dermatomyositis associated with muscle weakness and normal creatine kinase level
Auteurs : Christopher Kwan [Australie] ; Suzana Milosevic [Australie] ; Helen Benham [Australie] ; Ian A. Scott [Australie]Source :
- BMJ Case Reports [ 1757-790X ] ; 2020.
Abstract
We present a case study of a 61-year-old Vietnamese woman who presents with features of dermatomyositis (DM), including Gottron’s papules, heliotrope rash, cutaneous ulcers, generalised weakness and pain, and weight loss with normal levels of creatine kinase (CK). She demonstrated features of interstitial lung disease and subsequently tested positive for anti-melanoma differentiation-associated gene 5 and anti-small ubiquitin-like modifier 1 activating enzyme antibodies, which belong to a DM subtype known as clinically amyopathic dermatomyositis and do not present with raised CK. She received standard treatment for DM, including oral prednisolone, hydroxychloroquine, mycopheonlate and topical betamethasone. The treatment successfully reversed skin changes; however, the patient remained generally weak and unable to carry out her activities of daily living.
Url:
DOI: 10.1136/bcr-2019-232260
PubMed: 32033996
PubMed Central: 7021146
Affiliations:
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<front><div type="abstract" xml:lang="en"><p>We present a case study of a 61-year-old Vietnamese woman who presents with features of dermatomyositis (DM), including Gottron’s papules, heliotrope rash, cutaneous ulcers, generalised weakness and pain, and weight loss with normal levels of creatine kinase (CK). She demonstrated features of interstitial lung disease and subsequently tested positive for anti-melanoma differentiation-associated gene 5 and anti-small ubiquitin-like modifier 1 activating enzyme antibodies, which belong to a DM subtype known as clinically amyopathic dermatomyositis and do not present with raised CK. She received standard treatment for DM, including oral prednisolone, hydroxychloroquine, mycopheonlate and topical betamethasone. The treatment successfully reversed skin changes; however, the patient remained generally weak and unable to carry out her activities of daily living.</p>
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</author>
<author><name sortKey="Dastmalchi, M" uniqKey="Dastmalchi M">M Dastmalchi</name>
</author>
<author><name sortKey="Alexanderson, H" uniqKey="Alexanderson H">H Alexanderson</name>
</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Sadayama, T" uniqKey="Sadayama T">T Sadayama</name>
</author>
<author><name sortKey="Miyagawa, S" uniqKey="Miyagawa S">S Miyagawa</name>
</author>
<author><name sortKey="Shirai, T" uniqKey="Shirai T">T Shirai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Femia, An" uniqKey="Femia A">AN Femia</name>
</author>
<author><name sortKey="Eastham, Ab" uniqKey="Eastham A">AB Eastham</name>
</author>
<author><name sortKey="Lam, C" uniqKey="Lam C">C Lam</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bounfour, T" uniqKey="Bounfour T">T Bounfour</name>
</author>
<author><name sortKey="Bouaziz, J D" uniqKey="Bouaziz J">J-D Bouaziz</name>
</author>
<author><name sortKey="Bezier, M" uniqKey="Bezier M">M Bézier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="So, H" uniqKey="So H">H So</name>
</author>
<author><name sortKey="Wong, Vtl" uniqKey="Wong V">VTL Wong</name>
</author>
<author><name sortKey="Lao, Vwn" uniqKey="Lao V">VWN Lao</name>
</author>
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</TEI>
<affiliations><list><country><li>Australie</li>
</country>
</list>
<tree><country name="Australie"><noRegion><name sortKey="Kwan, Christopher" sort="Kwan, Christopher" uniqKey="Kwan C" first="Christopher" last="Kwan">Christopher Kwan</name>
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<name sortKey="Benham, Helen" sort="Benham, Helen" uniqKey="Benham H" first="Helen" last="Benham">Helen Benham</name>
<name sortKey="Milosevic, Suzana" sort="Milosevic, Suzana" uniqKey="Milosevic S" first="Suzana" last="Milosevic">Suzana Milosevic</name>
<name sortKey="Scott, Ian A" sort="Scott, Ian A" uniqKey="Scott I" first="Ian A" last="Scott">Ian A. Scott</name>
</country>
</tree>
</affiliations>
</record>
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